Although miracle whip is lower in calories and fat, you can use mayonnaise in its place. If you want to achieve the same sort of taste it is highly recommended that you put in some sugar.
There are going to be many different recipes where it is perfectly acceptable to substitute miracle whip for mayonnaise, though you will need to make sure that you use equal amounts when making this substitution.
Whether or not the mayonnaise turns out to compliment the dish will depend on a few different things, including which ingredients are used as well as your own personal preference. Some people like miracle whip while others prefer mayonnaise in their food.