There are certain foods that can trigger or cause acid reflux over time, though cantaloupe is not one of them. Those who have problems with acid reflux/heartburn will want to avoid eating highly acidic foods as well as ingesting a lot of caffeine. Hot peppers and chocolate are two other foods that can definitely contribute to acid reflux, so you will need to avoid them at all costs.
Some of the different foods which you will want to get lots of include apples, cherries, figs, pears, peaches, and of course cantaloupe. All of these fruits are considered to be alkaline which means that they are not acidic in nature and will not contribute to or worsen acid reflux at all.